sodium N-(N-choloylglycyl)taurinateTauroglycocholic acid sodium salt
sodium N-(N-choloylglycyl)taurinate
CAS: 41945-48-6;11006-55-6
Molecular Formula: C28H47N2NaO8S
sodium N-(N-choloylglycyl)taurinateTauroglycocholic acid sodium salt - Names and Identifiers
sodium N-(N-choloylglycyl)taurinateTauroglycocholic acid sodium salt - Physico-chemical Properties
| Molecular Formula | C28H47N2NaO8S |
| Molar Mass | 594.74 |
| Melting Point | >280°C (dec.) |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Appearance | Solid |
| Color | White to Off-White |
| Storage Condition | -20℃ |
sodium N-(N-choloylglycyl)taurinateTauroglycocholic acid sodium salt - Nature
Open Data Verified Data
- a mixture of sodium taurocholate and sodium glycinate extracted from bovine or porcine bile. For Brown yellow or light yellow powder; Fresh bile odor; Taste after the first sweet bitter; Hygroscopicity. Soluble in water, ethanol, insoluble in ether. Deliquescence in air.
- This product is beneficial to bile and promote the role of bile secretion, so that the secretion of bile and its components are increased. Bile salts contribute to the digestion of fat and promote its decomposition products through the intestinal mucosa of the water layer, it can increase fat and fat-soluble vitamins A, D, E, K absorption. It also increases the activity of pancreatic enzymes.
Last Update：2024-01-02 23:10:35
sodium N-(N-choloylglycyl)taurinateTauroglycocholic acid sodium salt - Preparation Method
Open Data Verified Data
The ingredients of this product are soluble sodium salts in bile. Bile or bile calcium salt extracted (see bilirubin process) after the bile solution with hydrochloric acid precipitation of bile salts. The crude product was dissolved in alcohol and sodium hydroxide was added and filtered. Decolorization, concentration, drying to obtain the finished product. The pig bile solution after extraction of biliary calcium salt was cooled to room temperature, and 6mol/L of industrial hydrochloric acid was slowly added with stirring so that the pH was 3.0 to 3.5, I .e., bile salts were precipitated. The upper layer of acid water was removed, and the paste was vacuum dried to obtain crude bile acid salt. The crude bile acid salt was dissolved in 6 times about 90% alcohol, allowed to stand for 24h, and filtered. Sodium hydroxide solution was added to the filtrate to a pH of 9-10, and 1% -2% of activated carbon was added, and th was decolorized by reflux, and carbon was removed by filtration. The filtrate was evaporated to dryness in the form of paste, vacuum dried, ball milled and sieved to obtain sodium cholate finished product.
Last Update：2022-01-01 09:27:26
sodium N-(N-choloylglycyl)taurinateTauroglycocholic acid sodium salt - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.681 ml | 8.407 ml | 16.814 ml |
| 5 mM | 0.336 ml | 1.681 ml | 3.363 ml |
| 10 mM | 0.168 ml | 0.841 ml | 1.681 ml |
| 5 mM | 0.034 ml | 0.168 ml | 0.336 ml |
Last Update：2024-01-02 23:10:35
sodium N-(N-choloylglycyl)taurinateTauroglycocholic acid sodium salt - Use
Open Data Verified Data
- choleretic drug. It can also be used as a surfactant in pharmaceutical preparations and the like.
- usage and dosage: 0. 1~0.4g, 3 times a day.
Last Update：2022-01-01 09:27:26
sodium N-(N-choloylglycyl)taurinateTauroglycocholic acid sodium salt - Safety
Open Data Verified Data
light shielding, closed storage.
Last Update：2022-01-01 11:14:07
sodium N-(N-choloylglycyl)taurinateTauroglycocholic acid sodium salt - Reference Information
| effect | bile acid is also an important signal molecule in addition to promoting fat-soluble food digestion. it plays a role in glucose and lipid metabolism by directly or indirectly activating the nuclear receptor farnicol x receptor (FXR) and membrane receptor g protein coupled bile acid receptor 5 (TGR5). Bile acids affect fat, glucose and energy metabolism by regulating certain genes. |
| Biological activity | Sodium tauroglycocholate is an inhibitor of the bile acid transport system of liver cells, and is also a surfactant used as a chemical penetration accelerator. |
Last Update：2024-04-09 19:05:12
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Product Name: Sodium tauroglycocholate Visit Supplier Webpage Request for quotationCAS: 41945-48-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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